The NCRI Teenage and Young Adult (TYA) and Germ Cell Tumours (GCT) Group is a multi-disciplinary community of researchers and consumers focused on clinical and translational issues relating to teenage and young adult and germ cell tumour research. The group works closely with clinical research networks, funders and national and international researchers to develop research to improve outcomes for teenage and young adult and germ cell tumour patients and identify areas of unmet need.

The group routinely identifies priorities in teenage and young adult and germ cell tumour research and dynamic working groups are established to address each priority.

NCRI Teenage and Young Adult (TYA) and Germ Cell Tumours (GCT) Group strategic priorities:

TYA & GCT Group

  • Identify the barriers resulting in a lack of diversity in patient and public involvement and engagement in developing TYA and GCT clinical trials and propose solutions to improve equality, diversity and inclusion.
  • Develop a platform study for newly diagnosed TYA cancer.
  • Identify the challenges faced in TYA and GCT research and propose solutions.
  • Improve early detection of cerebrovascular disease after cranial irradiation in patients under 40.
  • Improve outcomes for patients with early onset colorectal cancer.
  • Develop research questions relating to teenagers and young adults returning to education and the workplace after cancer.
  • Improve understanding of the genetics and genomics of treatment-resistant disease.
  • Identify immunology- and immunotherapy-related research questions that can be addressed using retrospective and prospective data.
  • Deliver an applied research programme on the impact of evidence-based risk-stratification on the clinical detection of late effects after TYA cancer.
  • Assess and improve end of life in teenagers and young adults with cancer.

GCT Study Group

  • Deliver an epidemiological and clinical study on GCTs in older patients.
  • Deliver the THERApy de-escalation trial for TESTicular cancer (THERATEST).
  • Deliver a multi-intervention study in seminoma.
  • Identify key questions in female germ cell cancer research and design a trial to address areas of unmet need.

NCRI TYA & GCT Group strategic priorities

How can I get involved?

Join the NCRI TYA & GCT Network

Group members

Professor Dan Stark

Chair

With a regional specialist clinical practice in Teenagers and Young Adults (TYA) with cancer, Ger ...

Professor Dan Stark

Chair

With a regional specialist clinical practice in Teenagers and Young Adults (TYA) with cancer, Germ cell tumours and sarcomas, I undertake clinical trial leadership and design for TYA with cancer, study quality of life & psychological wellbeing, and translational research in TYA cancer. I led an EU FP7 TYA research programme in this 2011-2016. I chair the 4th year undergraduate medical school theme ‘Research Evaluation and Special Studies’. I chair the National Cancer Research Institute Clinical Studies Group on Teenagers and Young Adults and Germ Cell tumours 2018-24.