Further research is needed to understand the impact of the Covid-19 pandemic on cancer prevention, health services and cancer patients.
The National Cancer Research Institute (NCRI), Cancer Research UK (CRUK) and Public Health England’s National Disease Registration Service (PHE NCRAS) hosted a Cancer/Covid-19 Research Summit with researchers from different disciplines discussing the impact that Covid-19 is having on cancer services and on research.
Several areas in which further research is needed were identified, as well as lessons from the pandemic to improve research, cancer care, and help prepare for future crises. These include understanding the biological and psychological effects of Covid-19 on cancer patients, risk factors associated with Covid-19 and cancer, the influence of Covid-19 on health-related behaviours and the impact of Covid-19 on cancer care pathways. The full meeting report can be found here.
Key themes identified in the discussions were:
Knowledge of and communication of risk
We saw a clear vulnerability in our understanding of infection risk in cancer patients, how we respond to these types of infections and how we effectively communicate evolving knowledge.
Being able to accurately assess an individual’s risk of Covid-19 is vital to inform their behaviour and how they seek or receive medical treatment. For cancer patients, this means understanding how risk factors such as cancer type, treatment type, immune system health and any other health issues influence their Covid-19 risk.
Researchers highlighted that policies and mitigation strategies, such as shielding advice and alterations to treatment pathways, were too broad and at times based on assumptions that lacked evidence. This likely resulted in missed cancer diagnoses and limited ability to provide cancer care.
While decision-makers acted on the best knowledge available to them at the time, we now know a great deal more about Covid-19. There needs to be a clearer process for translating such findings into practice and to inform policy. This will be important in dealing with Covid-19 and other crises, as well as improve how we assess and communicate infection risk in cancer patients to mitigate the impact of any future pandemics.
Impact on diagnosis and care pathways
We don’t have enough space on the board to move around the pieces when something goes wrong.
Covid-19 caused significant disruption across cancer screening, diagnosis, treatment and long-term care pathways. There is an opportunity to learn from this, for example by identifying care pathways or procedures that demonstrated greater resilience and developing strategies to manage sudden changes more effectively.
The number of missed cancer diagnoses was identified as a critical question. There is a concern that the drop in the number of two-week-wait referrals during the first wave of the pandemic indicates that several cancer cases may have been missed. It is a key priority to understand what happened to those people who would have normally been diagnosed with cancer.
Impact on health-related behaviours and effects on quality of life
Researchers asked what impact the Covid-19 pandemic or the resulting policy changes had on health behaviours, such as smoking and alcohol consumption, screening attendance and visiting primary and secondary care settings. Behavioural scientists highlighted that a persons’ perceived rather than actual risk is likely to affect these health behaviours; however, more research is needed to understand this.
The patient experience should be monitored closely in order to improve service delivery. This includes managing the effects of the pandemic on the quality of life of patients, carers, those shielding, and the NHS workforce.
There is research ongoing to understand the impact of the pandemic on mental health and wellbeing. Still, broader factors, including financial and social impacts, need to be assessed. It was stressed that this will help understand the impact the pandemic is having on cancer patients over time and identify any long-term issues that may need addressing.
Use of health data
The response to Covid-19 has demonstrated the benefits of collating and safely sharing data in real-time to support research and decision making. Building on this progress is not just invaluable for dealing with future emergencies, but for supporting the translation of research to improve healthcare under normal circumstances.
CRUK, PHE, NCRI and other organisations such as Health Data Research UK (HDR-UK) and NHS Digital have been working together to make significant progress in enabling a more transparent and effective way of identifying and accessing datasets to support research while keeping patients’ data secure. However, barriers to data-driven research still exist and they need to be reassessed in light of experiences during the pandemic so these tools can contribute to rapid progress in all disease areas and not just in times of crisis.
The pandemic has highlighted that research is an integral part of a well-functioning healthcare system. Lessons can be learned about how cancer-related research is conducted, how findings are translated into practice and how we as a community respond to crises.
- What changes in the care pathway occurred as a result of the pandemic and what has been the impact for cancer patients?
- What can we learn from colleagues working in infectious diseases about how to work together to tackle a health crisis?
- How can the collaborations and infrastructure built in response to Covid-19 be leveraged to identify, support and progress vital research in other disease areas?
- What lessons from the pandemic need to be captured and taken forward to help shape the future of health research and patient care?
These are some of the big questions that were raised, and we are only just reaching a point where we can begin to address them. We must continue to work together across cancer research, cancer care and beyond to ensure the legacy of the pandemic is not just one of adversity, but also of progress, preparedness and a better future for all.
 While members of CRUK, PHE & NCRI facilitated the meeting, the views represented in this meeting summary do not necessarily represent the views of their organisation.